Do we want to have gendered nouns/adjectives?
Maybe some kind of noun classes that aren't tied to gender?
That seems a good idea
Based on the words we have so far, I think the three options should be "-is" nominatives, "-ez" nominatives, and "-in" nominatives
How should those decline, then?
Tbh, imo, "-is" and "-ez" are far too similar sounding to really support different sets of inflections over a longer period. What you could have though is the nominative ending's grade of voicing influencing case inflections, so, idk, have a nominative in "-ez" turn the genitive (?) ending "-x" into "-g" or "-r" or whatever we would agree upon as a voiced equivalent to "x" (since the obvious option "ɣ" doesn't exist here).